Ontology highlight
ABSTRACT:
SUBMITTER: Shih W
PROVIDER: S-EPMC3445327 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Shih Wenting W Yamada Soichiro S
Journal of cell science 20120330 Pt 15
Cancer cells that originate from epithelial tissues typically lose epithelial specific cell-cell junctions, but these transformed cells are not devoid of cell-cell adhesion proteins. Using hepatocyte-growth-factor-treated MDCK cells that underwent a complete epithelial-to-mesenchymal transition, we analyzed cell-cell adhesion between these highly invasive transformed epithelial cells in a three-dimensional (3D) collagen matrix. In a 3D matrix, these transformed cells formed elongated multicellul ...[more]