Ontology highlight
ABSTRACT:
SUBMITTER: Chen Q
PROVIDER: S-EPMC6725471 | biostudies-literature | 2005 Jan
REPOSITORIES: biostudies-literature
Chen Qi Q Chen Tsan-Ju TJ Letourneau Paul C PC Costa Luciano Da F Lda F Schubert David D
The Journal of neuroscience : the official journal of the Society for Neuroscience 20050101 2
Modifier of cell adhesion (MOCA) is a member of the dedicator of cytokinesis 180 family of proteins and is highly expressed in CNS neurons. MOCA is associated with Alzheimer's disease tangles and regulates the accumulation of amyloid precursor protein and beta-amyloid. Here, we report that MOCA modulates cell-cell adhesion and morphology. MOCA increases the accumulation of adherens junction proteins, including N-cadherin and beta-catenin, whereas reducing endogenous MOCA expression lowers cell-c ...[more]