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Genetic architecture of body size in mammals.


ABSTRACT: Much of the heritability for human stature is caused by mutations of small-to-medium effect. This is because detrimental pleiotropy restricts large-effect mutations to very low frequencies.

SUBMITTER: Kemper KE 

PROVIDER: S-EPMC3446298 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature

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Genetic architecture of body size in mammals.

Kemper Kathryn E KE   Visscher Peter M PM   Goddard Michael E ME  

Genome biology 20120101 4


Much of the heritability for human stature is caused by mutations of small-to-medium effect. This is because detrimental pleiotropy restricts large-effect mutations to very low frequencies. ...[more]

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