Ontology highlight
ABSTRACT:
SUBMITTER: Marchini M
PROVIDER: S-EPMC4269856 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Marchini Marta M Sparrow Leah M LM Cosman Miranda N MN Dowhanik Alexandra A Krueger Carsten B CB Hallgrimsson Benedikt B Rolian Campbell C
BMC evolutionary biology 20141214
<h4>Background</h4>Mammals show a predictable scaling relationship between limb bone size and body mass. This relationship has a genetic basis which likely evolved via natural selection, but it is unclear how much the genetic correlation between these traits in turn impacts their capacity to evolve independently. We selectively bred laboratory mice for increases in tibia length independent of body mass, to test the hypothesis that a genetic correlation with body mass constrains evolutionary chan ...[more]