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Complete genome sequence of two coxsackievirus A1 strains that were cytotoxic to human rhabdomyosarcoma cells.

ABSTRACT: Coxsackievirus A1 (CVA1) belongs to human enterovirus species C within the family Picornaviridae, order Picornavirales. Two Chinese CVA1 isolates, HT-THLH02F/XJ/CHN/2011 and KS-ZPH01F/XJ/CHN/2011, were isolated from stool specimens of two healthy children in the Xinjiang Uygur autonomous region of China. They were found to elicit cytopathic effects in a human rhabdomyosarcoma cell line, and complete genome sequences of these two CVA1 isolates revealed that natural intertypic recombination events occurred between CVA1 and CVA22.

SUBMITTER: Sun Q

PROVIDER: S-EPMC3446563 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature

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Complete genome sequence of two coxsackievirus A1 strains that were cytotoxic to human rhabdomyosarcoma cells.

Sun Qiang Q Zhang Yong Y Zhu Shuangli S Cui Hui H Tian Huifang H Yan Dongmei D Huang Guohong G Zhu Zhen Z Wang Dongyan D Li Xiaolei X Jiang Huafang H An Hongqiu H Xu Wenbo W

Journal of virology 20120901 18

Coxsackievirus A1 (CVA1) belongs to human enterovirus species C within the family Picornaviridae, order Picornavirales. Two Chinese CVA1 isolates, HT-THLH02F/XJ/CHN/2011 and KS-ZPH01F/XJ/CHN/2011, were isolated from stool specimens of two healthy children in the Xinjiang Uygur autonomous region of China. They were found to elicit cytopathic effects in a human rhabdomyosarcoma cell line, and complete genome sequences of these two CVA1 isolates revealed that natural intertypic recombination events ...[more]

PMID: 22923792

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