Ontology highlight
ABSTRACT:
SUBMITTER: Chaudhry SI
PROVIDER: S-EPMC3446864 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Chaudhry S I SI Hooper S S Nye E E Williamson P P Harrington K K Sahai E E
Oncogene 20120326 6
The invasion of squamous cell carcinoma (SCC) is a significant cause of morbidity and mortality. Here, we identify an E3 ligase, Traf6 and a de-ubiquitinating enzyme, Cezanne/ZA20D1, as important regulators of this process in organotypic models. Traf6 can promote the formation of Cdc42-dependent F-actin microspikes. Furthermore, Traf6 has a key role in autocrine interleukin-1β signalling in SCC cells, which in turn is required to drive the expression of tumour necrosis factor α (TNFα). TNFα acts ...[more]