Assessment of gene-by-sex interaction effect on bone mineral density.
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ABSTRACT:
SUBMITTER: Liu CT
PROVIDER: S-EPMC3447125 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
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Assessment of gene-by-sex interaction effect on bone mineral density.
Liu Ching-Ti CT Estrada Karol K Yerges-Armstrong Laura M LM Amin Najaf N Evangelou Evangelos E Li Guo G Minster Ryan L RL Carless Melanie A MA Kammerer Candace M CM Oei Ling L Zhou Yanhua Y Alonso Nerea N Dailiana Zoe Z Eriksson Joel J García-Giralt Natalia N Giroux Sylvie S Husted Lise Bjerre LB Khusainova Rita I RI Koromila Theodora T Kung Annie Waichee AW Lewis Joshua R JR Masi Laura L Mencej-Bedrac Simona S Nogues Xavier X Nogues Xavier X Patel Millan S MS Prezelj Janez J Richards J Brent JB Sham Pak Chung PC Spector Timothy T Vandenput Liesbeth L Xiao Su-Mei SM Zheng Hou-Feng HF Zhu Kun K Balcells Susana S Brandi Maria Luisa ML Frost Morten M Goltzman David D González-Macías Jesús J Karlsson Magnus M Khusnutdinova Elza K EK Kollia Panagoula P Langdahl Bente Lomholt BL Ljunggren Osten O Lorentzon Mattias M Marc Janja J Mellström Dan D Ohlsson Claes C Olmos José M JM Ralston Stuart H SH Riancho José A JA Rousseau François F Urreizti Roser R Van Hul Wim W Zarrabeitia María T MT Castano-Betancourt Martha M Demissie Serkalem S Grundberg Elin E Herrera Lizbeth L Kwan Tony T Medina-Gómez Carolina C Pastinen Tomi T Sigurdsson Gunnar G Thorleifsson Gudmar G Vanmeurs Joyce Bj JB Blangero John J Hofman Albert A Liu Yongmei Y Mitchell Braxton D BD O'Connell Jeffrey R JR Oostra Ben A BA Rotter Jerome I JI Stefansson Kari K Streeten Elizabeth A EA Styrkarsdottir Unnur U Thorsteinsdottir Unnur U Tylavsky Frances A FA Uitterlinden Andre A Cauley Jane A JA Harris Tamara B TB Ioannidis John Pa JP Psaty Bruce M BM Robbins John A JA Zillikens M Carola MC Vanduijn Cornelia M CM Prince Richard L RL Karasik David D Rivadeneira Fernando F Kiel Douglas P DP Cupples L Adrienne LA Hsu Yi-Hsiang YH
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20121001 10
Sexual dimorphism in various bone phenotypes, including bone mineral density (BMD), is widely observed; however, the extent to which genes explain these sex differences is unclear. To identify variants with different effects by sex, we examined gene-by-sex autosomal interactions genome-wide, and performed expression quantitative trait loci (eQTL) analysis and bioinformatics network analysis. We conducted an autosomal genome-wide meta-analysis of gene-by-sex interaction on lumbar spine (LS) and f ...[more]
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