Revealing the role of phospholipase C?3 in the regulation of VEGF-induced vascular permeability.
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ABSTRACT:
SUBMITTER: Hoeppner LH
PROVIDER: S-EPMC3447777 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
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Revealing the role of phospholipase Cβ3 in the regulation of VEGF-induced vascular permeability.
Hoeppner Luke H LH Phoenix Kathryn N KN Clark Karl J KJ Bhattacharya Resham R Gong Xun X Sciuto Tracey E TE Vohra Pawan P Suresh Sandip S Bhattacharya Santanu S Dvorak Ann M AM Ekker Stephen C SC Dvorak Harold F HF Claffey Kevin P KP Mukhopadhyay Debabrata D
Blood 20120606 11
VEGF induces vascular permeability (VP) in ischemic diseases and cancer, leading to many pathophysiological consequences. The molecular mechanisms by which VEGF acts to induce hyperpermeability are poorly understood and in vivo models that easily facilitate real-time, genetic studies of VP do not exist. In the present study, we report a heat-inducible VEGF transgenic zebrafish (Danio rerio) model through which VP can be monitored in real time. Using this approach with morpholino-mediated gene kn ...[more]
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