Ontology highlight
ABSTRACT:
SUBMITTER: Wegmann F
PROVIDER: S-EPMC2118342 | biostudies-literature | 2006 Jul
REPOSITORIES: biostudies-literature
Wegmann Frank F Petri Björn B Khandoga Alexander Georg AG Moser Christian C Khandoga Andrej A Volkery Stefan S Li Hang H Nasdala Ines I Brandau Oliver O Fässler Reinhard R Butz Stefan S Krombach Fritz F Vestweber Dietmar D
The Journal of experimental medicine 20060703 7
Endothelial cell-selective adhesion molecule (ESAM) is specifically expressed at endothelial tight junctions and on platelets. To test whether ESAM is involved in leukocyte extravasation, we have generated mice carrying a disrupted ESAM gene and analyzed them in three different inflammation models. We found that recruitment of lymphocytes into inflamed skin was unaffected by the gene disruption. However, the migration of neutrophils into chemically inflamed peritoneum was inhibited by 70% at 2 h ...[more]