Ontology highlight
ABSTRACT:
SUBMITTER: Oduro KA
PROVIDER: S-EPMC3447779 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Blood 20120731 11
Skewing toward myeloid cell production is often observed in chronic inflammation and autoimmune diseases. Herein, we determined whether persistent myeloid activation and proinflammatory output occurring in pathologic conditions is at the level of hematopoietic stem and primitive progenitor cells (HSPPCs). By using a mouse arthritis model, we found that even though HSPPCs in arthritis still retained the capacity to differentiate into different lineages, they acquired enhanced in vitro and in vivo ...[more]