Ontology highlight
ABSTRACT:
SUBMITTER: Ruiz de Azua I
PROVIDER: S-EPMC3448777 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Ruiz de Azua Inigo I Nakajima Ken-ichiro K Rossi Mario M Cui Yinghong Y Jou William W Gavrilova Oksana O Wess Jürgen J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20120622 10
Spinophilin (SPL), a multidomain scaffolding protein known to modulate the activity of different G-protein-coupled receptors, regulates various central nervous system (CNS) functions. However, little is known about the role of SPL expressed in peripheral cell types including pancreatic β cells. In this study, we examined the ability of SPL to modulate the activity of β-cell M(3) muscarinic acetylcholine receptors (M3Rs), which play an important role in facilitating insulin release and maintainin ...[more]