Ontology highlight
ABSTRACT:
SUBMITTER: Yumoto N
PROVIDER: S-EPMC3448831 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Yumoto Norihiro N Kim Natalie N Burden Steven J SJ
Nature 20120801 7416
Motor axons receive retrograde signals from skeletal muscle that are essential for the differentiation and stabilization of motor nerve terminals. Identification of these retrograde signals has proved elusive, but their production by muscle depends on the receptor tyrosine kinase, MuSK (muscle, skeletal receptor tyrosine-protein kinase), and Lrp4 (low-density lipoprotein receptor (LDLR)-related protein 4), an LDLR family member that forms a complex with MuSK, binds neural agrin and stimulates Mu ...[more]