Investigating the genetic role of aquaporin4 gene in migraine.
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ABSTRACT:
SUBMITTER: Rubino E
PROVIDER: S-EPMC3451641 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Publications
Investigating the genetic role of aquaporin4 gene in migraine.
Rubino Elisa E Rainero I I Vaula G G Crasto F F Gravante E E Negro E E Brega F F Gallone S S Pinessi L L
The journal of headache and pain 20090210 2
Aquaporin4 (AQP4) has an important role in water homeostasis of human brain and a dysfunction of AQP4 could induce pathological conditions in neuronal activity. The purpose of our work was to evaluate the association of polymorphisms in the AQP4 gene with the risk and the clinical features of migraine. A total of 293 migraineurs and 249 controls were involved in the study. They were genotyped for four single nucleotide polymorphisms (SNPs) of AQP4 gene. No significant difference in the distribut ...[more]
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