Ontology highlight
ABSTRACT:
SUBMITTER: Periaswamy B
PROVIDER: S-EPMC3454430 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Periaswamy Balamurugan B Maier Lisa L Vishwakarma Vikalp V Slack Emma E Kremer Marcus M Andrews-Polymenis Helene L HL McClelland Michael M Grant Andrew J AJ Suar Mrutyunjay M Hardt Wolf-Dietrich WD
PloS one 20120924 9
Live attenuated vaccines are of great value for preventing infectious diseases. They represent a delicate compromise between sufficient colonization-mediated adaptive immunity and minimizing the risk for infection by the vaccine strain itself. Immune defects can predispose to vaccine strain infections. It has remained unclear whether vaccine safety could be improved via mutations attenuating a vaccine in immune-deficient individuals without compromising the vaccine's performance in the normal ho ...[more]