PolyMorphine: an innovative biodegradable polymer drug for extended pain relief.
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ABSTRACT:
SUBMITTER: Rosario-Melendez R
PROVIDER: S-EPMC3455147 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Publications
PolyMorphine: an innovative biodegradable polymer drug for extended pain relief.
Rosario-Meléndez Roselin R Harris Carolyn L CL Delgado-Rivera Roberto R Yu Lei L Uhrich Kathryn E KE
Journal of controlled release : official journal of the Controlled Release Society 20120803 3
Morphine, a potent narcotic analgesic used for the treatment of acute and chronic pain, was chemically incorporated into a poly(anhydride-ester) backbone. The polymer termed "PolyMorphine", was designed to degrade hydrolytically releasing morphine in a controlled manner to ultimately provide analgesia for an extended time period. PolyMorphine was synthesized via melt-condensation polymerization and its structure was characterized using proton and carbon nuclear magnetic resonance spectroscopies, ...[more]
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