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Ectoine biosynthesis in Mycobacterium smegmatis.

ABSTRACT: Mycobacterium smegmatis is a commonly used mycobacterial model system. Here, we show that M. smegmatis protects itself against elevated salinity by synthesizing ectoine and hydroxyectoine and characterize the phenotype of a nonproducing mutant. This is the first analysis of M. smegmatis halotolerance and of the molecular mechanism that supports it.

SUBMITTER: Ofer N 

PROVIDER: S-EPMC3457100 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature

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Ectoine biosynthesis in Mycobacterium smegmatis.

Ofer Naomi N   Wishkautzan Marina M   Meijler Michael M   Wang Ying Y   Speer Alexander A   Niederweis Michael M   Gur Eyal E  

Applied and environmental microbiology 20120810 20

Mycobacterium smegmatis is a commonly used mycobacterial model system. Here, we show that M. smegmatis protects itself against elevated salinity by synthesizing ectoine and hydroxyectoine and characterize the phenotype of a nonproducing mutant. This is the first analysis of M. smegmatis halotolerance and of the molecular mechanism that supports it. ...[more]

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