Ontology highlight
ABSTRACT:
SUBMITTER: Everts B
PROVIDER: S-EPMC3457738 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Everts Bart B Hussaarts Leonie L Driessen Nicole N NN Meevissen Moniek H J MH Schramm Gabriele G van der Ham Alwin J AJ van der Hoeven Barbara B Scholzen Thomas T Burgdorf Sven S Mohrs Markus M Pearce Edward J EJ Hokke Cornelis H CH Haas Helmut H Smits Hermelijn H HH Yazdanbakhsh Maria M
The Journal of experimental medicine 20120910 10
Omega-1, a glycosylated T2 ribonuclease (RNase) secreted by Schistosoma mansoni eggs and abundantly present in soluble egg antigen, has recently been shown to condition dendritic cells (DCs) to prime Th2 responses. However, the molecular mechanisms underlying this effect remain unknown. We show in this study by site-directed mutagenesis of omega-1 that both the glycosylation and the RNase activity are essential to condition DCs for Th2 polarization. Mechanistically, we demonstrate that omega-1 i ...[more]