Ontology highlight
ABSTRACT:
SUBMITTER: Williams JW
PROVIDER: S-EPMC4003872 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Williams Jesse W JW Tjota Melissa Y MY Clay Bryan S BS Vander Lugt Bryan B Bandukwala Hozefa S HS Hrusch Cara L CL Decker Donna C DC Blaine Kelly M KM Fixsen Bethany R BR Singh Harinder H Sciammas Roger R Sperling Anne I AI
Nature communications 20130101
Atopic asthma is an inflammatory pulmonary disease associated with Th2 adaptive immune responses triggered by innocuous antigens. While dendritic cells (DCs) are known to shape the adaptive immune response, the mechanisms by which DCs promote Th2 differentiation remain elusive. Herein we demonstrate that Th2-promoting stimuli induce DC expression of IRF4. Mice with conditional deletion of Irf4 in DCs show a dramatic defect in Th2-type lung inflammation, yet retain the ability to elicit pulmonary ...[more]