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A meta-analysis of apolipoprotein E gene ?2/?3/?4 polymorphism for gallbladder stone disease.

ABSTRACT: BACKGROUND: Numerous studies have investigated the relationship between apolipoprotein (Apo) E gene polymorphisms and gallbladder stone disease (GSD) across ethnic populations; however, the results are often inconsistent. This meta-analysis aims to comprehensively evaluate the influence of a common ?2/?3/?4 polymorphism in Apo E gene on the risk of gallbladder stone disease. METHOD: Data were analyzed using the RevMan software (V5.1) and a random-effects model was applied irrespective of between-study heterogeneity. Publication bias was weighed using the fail-safe number. RESULTS: There were 17 study populations totaling 1773 cases and 2751 controls for ?2/?3/?4 polymorphism of Apo E gene. Overall comparison of alleles ?2 with ?3 in all study populations yielded a 16% decreased risk for GSD (95% confidence interval [95% CI]: 0.68-1.05; P=0.31; I(2)?=13%), and comparison of alleles ?4 with ?3 yielded a 25% increased risk (95% confidence interval [95% CI]: 0.97-1.61; P=0.0003; I(2)?=63%). Subgroup analysis by study design indicated that the magnitude of association in hospital-based studies was largely significantly strengthened for ?4 allelic model (odds ratio [OR] ?=1.46; 95% CI: 1.05-2.02; p=0.0007; I(2)?=65%). Subgroup analysis by age of controls indicated a remarkably significant elevation in the magnitude of association in age >50 subgroups in ?4 allelic model (OR=1.50; 95% CI: 1.03-2.19; p=0.0009; I(2)?=72%). Moreover, subgroup analysis by cases gender indicated a reduction in the magnitude of association in male<30% studies for E2/2 genotypic model (OR=0.32; 95% CI: 0.07-1.49; p=0.16; I(2)?=45%). CONCLUSIONS: Our results reveal that Apo E gene ?4 allele is a risk factor of gallbladder stone disease, especially in elder people and Chinese population.

SUBMITTER: Xue P

PROVIDER: S-EPMC3458111 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature

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A meta-analysis of apolipoprotein E gene ε2/ε3/ε4 polymorphism for gallbladder stone disease.

Xue Pei P Niu Wen-Quan WQ Jiang Zhao-Yan ZY Zheng Min-Hua MH Fei Jian J

PloS one 20120925 9

<h4>Background</h4>Numerous studies have investigated the relationship between apolipoprotein (Apo) E gene polymorphisms and gallbladder stone disease (GSD) across ethnic populations; however, the results are often inconsistent. This meta-analysis aims to comprehensively evaluate the influence of a common ε2/ε3/ε4 polymorphism in Apo E gene on the risk of gallbladder stone disease.<h4>Method</h4>Data were analyzed using the RevMan software (V5.1) and a random-effects model was applied irrespecti ...[more]

PMID: 23049877

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Project description:Polymorphisms in the apolipoprotein C-III (APOC3) gene have been reported to be associated with coronary heart disease (CHD), but the data so far have been conflicting. To derive a more precise estimation of these associations, we performed a meta-analysis to investigate the three main polymorphisms (SstI, T-455C, C-482T) of APOC3 in all published studies. Databases including PubMed, Web of Science, Wanfang, SinoMed and CNKI were systematically searched. The association was assessed using odds ratios (ORs) with 95% confidence intervals (CIs). The statistical analysis was performed using Review Manager 5.3.3 and Stata 12.0. A total of 31 studies have been identified. The pooled odds ratio (OR) for the association between the APOC3 gene polymorphisms and CHD and its corresponding 95% confidence interval (95% CI) were evaluated by random or fixed effect models. A statistical association between APOC3 SstI polymorphism and CHD susceptibility was observed under an allelic contrast model (P= 0.003, OR = 1.14, 95% CI = 1.05-1.24), dominant genetic model (P= 0.01, OR = 1.14, 95% CI = 1.03-1.26), and recessive genetic model (P= 0.02, OR = 1.35, 95% CI = 1.06-1.71), respectively. A significant association between the APOC3 T-455C polymorphism and CHD was also detected under an allelic contrast (P < 0.0001, OR = 1.19, 95% CI = 1.10-1.29), dominant genetic model (P= 0.0003, OR = 1.24, 95% CI = 1.11-1.39) and recessive genetic model (P= 0.04, OR = 1.30, 95% CI = 1.01-1.67). No significant association between the APOC3 C-482T polymorphism and CHD was found under an allelic model (P= 0.94, OR = 1.00, 95% CI = 0.93-1.08), dominant genetic model (P= 0.20, OR = 1.07, 95% CI = 0.97-1.18) or recessive genetic model (P= 0.13, OR = 0.90, 95% CI = 0.79-1.03). This meta-analysis revealed that the APOC3 SstI and T-455C polymorphisms significantly increase CHD susceptibility. No significant association was observed between the APOC3 C-482T polymorphism and CHD susceptibility.

Dataset Information

A meta-analysis of apolipoprotein E gene ?2/?3/?4 polymorphism for gallbladder stone disease.

Publications

A meta-analysis of apolipoprotein E gene ε2/ε3/ε4 polymorphism for gallbladder stone disease.

Similar Datasets

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