Meta-analysis of apolipoprotein E gene polymorphism and susceptibility of myocardial infarction.

ABSTRACT: A number of case-control studies have been conducted to clarify the association between ApoE polymorphisms and myocardial infarction (MI); however, the results are inconsistent. This meta-analysis was performed to clarify this issue using all the available evidence. Searching in PubMed retrieved all eligible articles. A total of 33 studies were included in this meta-analysis, including 18752 MI cases and 18963 controls. The pooled analysis based on all included studies showed that the MI patients had a decreased frequency of the ?2 allele (OR?=?0.78, 95% CI?=?0.70-0.87) and an increased frequency of the ?4 allele (OR?=?1.15, 95% CI?=?1.10-1.20); The results also showed a decreased susceptibility of MI in the ?2?3 vs. ?3?3 analysis (OR?=?0.79, 95% CI?=?0.68-0.90) and in the ?2 vs. ?3 analysis (OR?=?0.78, 95% CI?=?0.69-0.89), an increased susceptibility of MI in the ?3?4 vs. ?3?3 analysis (OR?=?1.26, 95% CI?=?1.12-1.41), in the ?4 vs. ?3 analysis (OR?=?1.22, 95% CI?=?1.12-1.32) and in the ?4?4 vs. ?3?3 analysis (OR?=?1.59, 95% CI?=?1.15-2.19). However, there were no significant associations among polymorphisms and MI for the following genetic models: frequency of the ?3 allele (OR?=?0.99, 95% CI?=?0.96-1.02); ?2?2 vs. ?3?3 analysis (OR?=?0.73, 95% CI?=?0.40-1.32); or ?2?4 vs. ?3?3 analysis (OR?=?1.10, 95% CI?=?0.99-1.21). Our results suggested that the ?4 allele of ApoE is a risk factor for the development of MI and the ?2 allele of ApoE is a protective factor in the development of MI.

SUBMITTER: Xu H 

PROVIDER: S-EPMC4128680 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature