Ontology highlight
ABSTRACT:
SUBMITTER: Simpson N
PROVIDER: S-EPMC3458225 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Simpson Norman N Maffei Antonella A Freeby Matthew M Burroughs Steven S Freyberg Zachary Z Javitch Jonathan J Leibel Rudolph L RL Harris Paul E PE
Molecular endocrinology (Baltimore, Md.) 20120821 10
We describe a negative feedback autocrine regulatory circuit for glucose-stimulated insulin secretion in purified human islets in vitro. Using chronoamperometry and in vitro glucose-stimulated insulin secretion measurements, evidence is provided that dopamine (DA), which is loaded into insulin-containing secretory granules by vesicular monoamine transporter type 2 in human β-cells, is released in response to glucose stimulation. DA then acts as a negative regulator of insulin secretion via its a ...[more]