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Synthesis of a novel chemotype via sequential metal-catalyzed cycloisomerizations.


ABSTRACT: Sequential cycloisomerizations of diynyl o-benzaldehyde substrates to access novel polycyclic cyclopropanes are reported. The reaction sequence involves initial Cu(I)-mediated cycloisomerization/nucleophilic addition to an isochromene followed by diastereoselective Pt(II)-catalyzed enyne cycloisomerization.

SUBMITTER: Leng B 

PROVIDER: S-EPMC3458758 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature

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Synthesis of a novel chemotype via sequential metal-catalyzed cycloisomerizations.

Leng Bo B   Chichetti Stephanie S   Su Shun S   Beeler Aaron B AB   Porco John A JA  

Beilstein journal of organic chemistry 20120820


Sequential cycloisomerizations of diynyl o-benzaldehyde substrates to access novel polycyclic cyclopropanes are reported. The reaction sequence involves initial Cu(I)-mediated cycloisomerization/nucleophilic addition to an isochromene followed by diastereoselective Pt(II)-catalyzed enyne cycloisomerization. ...[more]

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