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A sequential metal-catalyzed C-N bond formation in the synthesis of 2-amido-indoles.

ABSTRACT: A sequential metal-catalyzed C-N bond formation employing ortho-haloaryl acetylenic bromides is described. The initial amidation is highly selective for C (sp)-N bond formation, leading to o-haloaryl-substituted ynamides that can be useful building blocks, while the overall sequence provides a facile construction of 2-amido-indoles.

SUBMITTER: Yao PY

PROVIDER: S-EPMC2662137 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature

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A sequential metal-catalyzed C-N bond formation in the synthesis of 2-amido-indoles.

Yao Pei-Yuan PY Zhang Yu Y Hsung Richard P RP Zhao Kang K

Organic letters 20080828 19

A sequential metal-catalyzed C-N bond formation employing ortho-haloaryl acetylenic bromides is described. The initial amidation is highly selective for C (sp)-N bond formation, leading to o-haloaryl-substituted ynamides that can be useful building blocks, while the overall sequence provides a facile construction of 2-amido-indoles. ...[more]

PMID: 18754591

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