Ontology highlight
ABSTRACT:
SUBMITTER: Frings M
PROVIDER: S-EPMC3458769 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Beilstein journal of organic chemistry 20120903
For the first time, chiral sulfoximine derivatives have been applied as asymmetric organocatalysts. In combination with a thiourea-type backbone the sulfonimidoyl moiety leads to organocatalysts showing good reactivity in the catalytic desymmetrization of a cyclic meso-anhydride and moderate enantioselectivity in the catalytic asymmetric Biginelli reaction. Straightforward synthetic routes provide the newly designed thiourea-sulfoximine catalysts in high overall yields without affecting the ster ...[more]