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Cross-trienamines in asymmetric organocatalysis.

ABSTRACT: Cross-conjugated trienamines are introduced as a new concept in asymmetric organocatalysis. These intermediates are applied in highly enantioselective Diels-Alder and addition reactions, providing functionalized bicyclo[2.2.2]octane compounds and γ'-addition products, respectively. The nature of the transformations and the intermediates involved are investigated by computational calculations and NMR analysis.

SUBMITTER: Halskov KS

PROVIDER: S-EPMC3557926 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature

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Cross-trienamines in asymmetric organocatalysis.

Halskov Kim Søholm KS Johansen Tore Kiilerich TK Davis Rebecca L RL Steurer Marianne M Jensen Frank F Jørgensen Karl Anker KA

Journal of the American Chemical Society 20120730 31

Cross-conjugated trienamines are introduced as a new concept in asymmetric organocatalysis. These intermediates are applied in highly enantioselective Diels-Alder and addition reactions, providing functionalized bicyclo[2.2.2]octane compounds and γ'-addition products, respectively. The nature of the transformations and the intermediates involved are investigated by computational calculations and NMR analysis. ...[more]

PMID: 22835208

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