Respiratory pathogens adopt a chronic lifestyle in response to bile.
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ABSTRACT:
SUBMITTER: Reen FJ
PROVIDER: S-EPMC3458808 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Publications
Respiratory pathogens adopt a chronic lifestyle in response to bile.
Reen F Jerry FJ Woods David F DF Mooij Marlies J MJ Adams Claire C O'Gara Fergal F
PloS one 20120926 9
Chronic respiratory infections are a major cause of morbidity and mortality, most particularly in Cystic Fibrosis (CF) patients. The recent finding that gastro-esophageal reflux (GER) frequently occurs in CF patients led us to investigate the impact of bile on the behaviour of Pseudomonas aeruginosa and other CF-associated respiratory pathogens. Bile increased biofilm formation, Type Six Secretion, and quorum sensing in P. aeruginosa, all of which are associated with the switch from acute to per ...[more]
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