Ontology highlight
ABSTRACT:
SUBMITTER: Zhao T
PROVIDER: S-EPMC3459055 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Zhao Tongtong T Graham Owen S OS Raposo Alexandre A St Johnston Daniel D
Science (New York, N.Y.) 20120412 6084
The Drosophila dorsal-ventral (DV) axis is polarized when the oocyte nucleus migrates from the posterior to the anterior margin of the oocyte. Prior work suggested that dynein pulls the nucleus to the anterior side along a polarized microtubule cytoskeleton, but this mechanism has not been tested. By imaging live oocytes, we find that the nucleus migrates with a posterior indentation that correlates with its direction of movement. Furthermore, both nuclear movement and the indentation depend on ...[more]