Ontology highlight
ABSTRACT:
SUBMITTER: Zimanyi CM
PROVIDER: S-EPMC3459064 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Structure (London, England : 1993) 20120621 8
Ribonucleotide reductases (RNRs) provide the precursors for DNA biosynthesis and repair and are successful targets for anticancer drugs such as clofarabine and gemcitabine. Recently, we reported that dATP inhibits E. coli class Ia RNR by driving formation of RNR subunits into α4β4 rings. Here, we present the first X-ray structure of a gemcitabine-inhibited E. coli RNR and show that the previously described α4β4 rings can interlock to form an unprecedented (α4β4)2 megacomplex. This complex is als ...[more]