High genomic instability predicts survival in metastatic high-risk neuroblastoma.
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ABSTRACT:
SUBMITTER: Stigliani S
PROVIDER: S-EPMC3459278 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Publications
High genomic instability predicts survival in metastatic high-risk neuroblastoma.
Stigliani Sara S Coco Simona S Moretti Stefano S Oberthuer Andrè A Fischer Mattias M Theissen Jessica J Gallo Fabio F Garavent Alberto A Berthold Frank F Bonassi Stefano S Tonini Gian Paolo GP Scaruffi Paola P
Neoplasia (New York, N.Y.) 20120901 9
We aimed to identify novel molecular prognostic markers to better predict relapse risk estimate for children with high-risk (HR) metastatic neuroblastoma (NB). We performed genome- and/or transcriptome-wide analyses of 129 stage 4 HR NBs. Children older than 1 year of age were categorized as "short survivors" (dead of disease within 5 years from diagnosis) and "long survivors" (alive with an overall survival time ≥ 5 years). We reported that patients with less than three segmental copy number ab ...[more]
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