Ontology highlight
ABSTRACT:
SUBMITTER: Tili E
PROVIDER: S-EPMC3460685 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Blood 20120621 13
MiR-125b-1 maps at 11q24, a chromosomal region close to the epicenter of 11q23 deletions in chronic lymphocytic leukemias (CLLs). Our results establish that both aggressive and indolent CLL patients show reduced expression of miR-125b. Overexpression of miR-125b in CLL-derived cell lines resulted in the repression of many transcripts encoding enzymes implicated in cell metabolism. Metabolomics analyses showed that miR-125b overexpression modulated glucose, glutathione, lipid, and glycerolipid me ...[more]