Ontology highlight
ABSTRACT:
SUBMITTER: Speak AO
PROVIDER: S-EPMC3461304 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Speak Anneliese O AO Platt Nicholas N Salio Mariolina M te Vruchte Danielle D Smith David A DA Shepherd Dawn D Veerapen Natacha N Besra Gurdyal S GS Yanjanin Nicole M NM Simmons Louise L Imrie Jackie J Wraith James E JE Lachmann Robin H RH Hartung Ralf R Runz Heiko H Mengel Eugen E Beck Michael M Hendriksz Christian J CJ Porter Forbes D FD Cerundolo Vincenzo V Platt Frances M FM
European journal of immunology 20120614 7
Invariant natural killer T (iNKT) cells are a specialised subset of T cells that are restricted to the MHC class I like molecule, CD1d. The ligands for iNKT cells are lipids, with the canonical superagonist being α-galactosylceramide, a non-mammalian glycosphingolipid. Trafficking of CD1d through the lysosome is required for the development of murine iNKT cells. Niemann-Pick type C (NPC) disease is a lysosomal storage disorder caused by dysfunction in either of two lysosomal proteins, NPC1 or NP ...[more]