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Autoproteolytic fragments are intermediates in the oligomerization/aggregation of the Parkinson's disease protein alpha-synuclein as revealed by ion mobility mass spectrometry.


ABSTRACT: Gas-phase protein separation by ion mobility: With its ability to separate the Parkinson's disease protein ?-synuclein and its autoproteolytic products-despite the small concentrations of the latter-ion-mobility MS has enabled the characterization of intermediate fragments in in vitro oligomerization-aggregation. In particular, a possible key fragment, the highly aggregating C-terminal fragment, ?Syn(72-140), has been revealed.

SUBMITTER: Vlad C 

PROVIDER: S-EPMC3461308 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature

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Autoproteolytic fragments are intermediates in the oligomerization/aggregation of the Parkinson's disease protein alpha-synuclein as revealed by ion mobility mass spectrometry.

Vlad Camelia C   Lindner Kathrin K   Karreman Christiaan C   Schildknecht Stefan S   Leist Marcel M   Tomczyk Nick N   Rontree John J   Langridge James J   Danzer Karin K   Ciossek Thomas T   Petre Alina A   Gross Michael L ML   Hengerer Bastian B   Przybylski Michael M  

Chembiochem : a European journal of chemical biology 20111107 18


Gas-phase protein separation by ion mobility: With its ability to separate the Parkinson's disease protein α-synuclein and its autoproteolytic products-despite the small concentrations of the latter-ion-mobility MS has enabled the characterization of intermediate fragments in in vitro oligomerization-aggregation. In particular, a possible key fragment, the highly aggregating C-terminal fragment, αSyn(72-140), has been revealed. ...[more]

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