Ontology highlight
ABSTRACT:
SUBMITTER: Paliwal P
PROVIDER: S-EPMC3461343 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Paliwal Preeti P Pishesha Novalia N Wijaya Denny D Conboy Irina M IM
Aging 20120801 8
Skeletal muscle regeneration following injury is accompanied by rapid infiltration of macrophages, which play a positive role in muscle repair. Increased chronic inflammation inhibits the regeneration of dystrophic muscle, but the properties of inflammatory cells are not well understood in the context of normal muscle aging. This work uncovers pronounced age-specific changes in the expression of osteopontin (OPN) in CD11b+ macrophages present in the injured old muscle as well as in the blood ser ...[more]