Ontology highlight
ABSTRACT:
SUBMITTER: Gingras AR
PROVIDER: S-EPMC3461514 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Gingras Alexandre R AR Liu Jian J JJ Ginsberg Mark H MH
The Journal of cell biology 20120924 1
The products of genes that cause cerebral cavernous malformations (CCM1/KRIT1, CCM2, and CCM3) physically interact. CCM1/KRIT1 links this complex to endothelial cell (EC) junctions and maintains junctional integrity in part by inhibiting RhoA. Heart of glass (HEG1), a transmembrane protein, associates with KRIT1. In this paper, we show that the KRIT1 band 4.1, ezrin, radixin, and moesin (FERM) domain bound the HEG1 C terminus (K(d) = 1.2 µM) and solved the structure of this assembly. The KRIT1 F ...[more]