Biosynthesis of piperazic acid via N5-hydroxy-ornithine in Kutzneria spp. 744.
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ABSTRACT:
SUBMITTER: Neumann CS
PROVIDER: S-EPMC3463134 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Publications
Biosynthesis of piperazic acid via N5-hydroxy-ornithine in Kutzneria spp. 744.
Neumann Christopher S CS Jiang Wei W Heemstra John R JR Gontang Erin A EA Kolter Roberto R Walsh Christopher T CT
Chembiochem : a European journal of chemical biology 20120420 7
Which came first? We have investigated the biosynthesis of the piperazic acid (Piz) building blocks in the kutzneride family of metabolites. The flavin-dependent oxygenase KtzI was shown to convert ornithine to N(5)-OH-Orn. LC-MS/MS showed (13)C(5)-labeled versions of these two amino acids to be direct precursors of piperazic acid in vivo. ...[more]
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