Cerebrospinal fluid proteome of patients with acute Lyme disease.
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ABSTRACT:
SUBMITTER: Angel TE
PROVIDER: S-EPMC3465517 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Publications
Cerebrospinal fluid proteome of patients with acute Lyme disease.
Angel Thomas E TE Jacobs Jon M JM Smith Robert P RP Pasternack Mark S MS Elias Susan S Gritsenko Marina A MA Shukla Anil A Gilmore Edward C EC McCarthy Carol C Camp David G DG Smith Richard D RD Warren H Shaw HS
Journal of proteome research 20120831 10
During acute Lyme disease, bacteria can disseminate to the central nervous system (CNS), leading to the development of meningitis and other neurologic symptoms. Here we have analyzed pooled cerebrospinal fluid (CSF) allowing a deep view into the proteome for patients diagnosed with early disseminated Lyme disease and CSF inflammation. Additionally, we analyzed individual patient samples and quantified differences in protein abundance employing label-free quantitative mass spectrometry-based meth ...[more]
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