Ontology highlight
ABSTRACT:
SUBMITTER: Taggart AJ
PROVIDER: S-EPMC3465671 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Taggart Allison J AJ DeSimone Alec M AM Shih Janice S JS Filloux Madeleine E ME Fairbrother William G WG
Nature structural & molecular biology 20120617 7
We present the first large-scale identification of lariats-the transient branched introns that are released as a byproduct of pre-mRNA splicing. The locations of the branchpoints in these introns provide insight into the early steps of splicing. From this data set, we have developed a comprehensive model of 3' splice-site selection, identified new mechanisms of alternative splicing and mapped the distribution of splicing factors around branchpoints. ...[more]