Ontology highlight
ABSTRACT:
SUBMITTER: Bao J
PROVIDER: S-EPMC3465688 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Bao Ju J Zheng Jie J JJ Wu Dianqing D
Science signaling 20120515 224
Low-density lipoprotein receptor-related proteins 5 and 6 (LRP5/6) mediate canonical Wnt-β-catenin signaling by forming a complex with the co-receptor Frizzled, which binds to Wnt proteins. Dickkopf (DKK)-related proteins inhibit the Wnt signaling pathway by directly binding to the ectodomains of LRP5/6. However, the mechanism for DKK-mediated antagonism has not been fully understood as of yet. Crystal structures of the LRP6 ectodomain in complex with DKK1, along with mutagenesis studies, provid ...[more]