Ontology highlight
ABSTRACT:
SUBMITTER: Nygaard R
PROVIDER: S-EPMC7797000 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Cell 20201223 1
Wnts are evolutionarily conserved ligands that signal at short range to regulate morphogenesis, cell fate, and stem cell renewal. The first and essential steps in Wnt secretion are their O-palmitoleation and subsequent loading onto the dedicated transporter Wntless/evenness interrupted (WLS/Evi). We report the 3.2 Å resolution cryogenic electron microscopy (cryo-EM) structure of palmitoleated human WNT8A in complex with WLS. This is accompanied by biochemical experiments to probe the physiologic ...[more]