Ontology highlight
ABSTRACT:
SUBMITTER: Ustyugova IV
PROVIDER: S-EPMC3465947 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Ustyugova Irina V IV Zhi Liang L Abramowitz Joel J Birnbaumer Lutz L Wu Mei X MX
Molecular cancer research : MCR 20120501 6
The immediate early response gene X-1 (IEX-1) is involved in regulation of various cellular processes including proliferation, apoptosis in part by controlling homeostasis of reactive oxygen species (ROS) at mitochondria. The present study shows reduced inflammatory responses and colorectal cancer in IEX-1 knockout (KO) mice treated with azoxymethane/dextran sulfate sodium (DSS). However, DSS induced worse colitis in RAG(-/-)IEX-1(-/-) double KO mice than in RAG and IEX-1 single KO mice, undersc ...[more]