Ontology highlight
ABSTRACT:
SUBMITTER: Meljon A
PROVIDER: S-EPMC3466016 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Meljon Anna A Theofilopoulos Spyridon S Shackleton Cedric H L CH Watson Gordon L GL Javitt Norman B NB Knölker Hans-Joachim HJ Saini Ratni R Arenas Ernest E Wang Yuqin Y Griffiths William J WJ
Journal of lipid research 20120813 11
Unesterified cholesterol is a major component of plasma membranes. In the brain of the adult, it is mostly found in myelin sheaths, where it plays a major architectural role. In the newborn mouse, little myelination of neurons has occurred, and much of this sterol comprises a metabolically active pool. In the current study, we have accessed this metabolically active pool and, using LC/MS, have identified cholesterol precursors and metabolites. Although desmosterol and 24S-hydroxycholesterol repr ...[more]