Structure and biosynthesis of the antibiotic bottromycin D.
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ABSTRACT:
SUBMITTER: Hou Y
PROVIDER: S-EPMC3466018 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Publications
Structure and biosynthesis of the antibiotic bottromycin D.
Hou Yanpeng Y Tianero Ma Diarey B MD Kwan Jason C JC Wyche Thomas P TP Michel Cole R CR Ellis Gregory A GA Vazquez-Rivera Emmanuel E Braun Doug R DR Rose Warren E WE Schmidt Eric W EW Bugni Tim S TS
Organic letters 20120917 19
Drug resistant infectious diseases are quickly becoming a global health crisis. While Streptomyces spp. have been a major source of antibiotics over the past 50 years, efficient methods are needed to identify new antibiotics and greatly improve the rate of discovery. LCMS-based metabolomics were applied to analyze extracts of 50 Streptomyes spp. Using this methodology, we discovered bottromycin D and used whole genome sequencing to determine its biosynthesis by a ribosomal pathway. ...[more]
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