Ontology highlight
ABSTRACT:
SUBMITTER: Neelarapu R
PROVIDER: S-EPMC3466118 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Journal of medicinal chemistry 20110602 13
The design, synthesis, docking, and biological evaluation of novel potent HDAC3 and HDAC8 isoxazole- and pyrazole-based diazide probes suitable for binding ensemble profiling with photoaffinity labeling (BEProFL) experiments in cells is described. Both the isoxazole- and pyrazole-based probes exhibit low nanomolar inhibitory activity against HDAC3 and HDAC8, respectively. The pyrazole-based probe 3f appears to be one of the most active HDAC8 inhibitors reported in the literature with an IC(50) o ...[more]