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Design, Synthesis, and Biological Activities of Novel Pyrazole Oxime Compounds Containing a Substituted Pyridyl Moiety.

ABSTRACT: In this paper, in order to find novel biologically active pyrazole oximes, a series of pyrazole oxime compounds bearing a substituted pyridyl unit were prepared. Bioassays showed that some target compounds were found to have good acaricidal activity against Tetranychus cinnabarinus at a concentration of 500 ?g/mL, compound 9q especially displayed potent acaricidal activity against T. cinnabarinus when the concentration was reduced to 100 ?g/mL. Interestingly, most target compounds possessed excellent insecticidal activities against Oriental armyworm at 500 ?g/mL. Moreover, some compounds were active against Aphis medicaginis and Nilaparvata lugens at 500 ?g/mL. Additionally, compounds 9b, 9g, 9l, 9p, 9q, 9r, 9s, 9t, 9u, and 9v displayed significant antiproliferative activities against HepG2 cells with IC50 values of 1.53-17.27 ?M, better than that of the control 5-fluorouracil (IC50 = 35.67 ?M).

SUBMITTER: Chen C

PROVIDER: S-EPMC6152754 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature

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Design, Synthesis, and Biological Activities of Novel Pyrazole Oxime Compounds Containing a Substituted Pyridyl Moiety.

Chen Cuili C Chen Jia J Gu Haiying H Bao Ning N Dai Hong H

Molecules (Basel, Switzerland) 20170525 6

In this paper, in order to find novel biologically active pyrazole oximes, a series of pyrazole oxime compounds bearing a substituted pyridyl unit were prepared. Bioassays showed that some target compounds were found to have good acaricidal activity against Tetranychus cinnabarinus at a concentration of 500 μg/mL, compound 9q especially displayed potent acaricidal activity against T. cinnabarinus when the concentration was reduced to 100 μg/mL. Interestingly, most target com ...[more]

PMID: 28587083

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