Rapamycin ameliorates age-dependent obesity associated with increased mTOR signaling in hypothalamic POMC neurons.
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ABSTRACT:
SUBMITTER: Yang SB
PROVIDER: S-EPMC3467009 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
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Rapamycin ameliorates age-dependent obesity associated with increased mTOR signaling in hypothalamic POMC neurons.
Yang Shi-Bing SB Tien An-Chi AC Boddupalli Gayatri G Xu Allison W AW Jan Yuh Nung YN Jan Lily Yeh LY
Neuron 20120801 3
<h4>Video abstract</h4>The prevalence of obesity in older people is the leading cause of metabolic syndromes. Central neurons serving as homeostatic sensors for body-weight control include hypothalamic neurons that express pro-opiomelanocortin (POMC) or neuropeptide-Y (NPY) and agouti-related protein (AgRP). Here, we report an age-dependent increase of mammalian target of rapamycin (mTOR) signaling in POMC neurons that elevates the ATP-sensitive potassium (K(ATP)) channel activity cell-autonomou ...[more]
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