Ontology highlight
ABSTRACT:
SUBMITTER: Ordenes P
PROVIDER: S-EPMC8569171 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Órdenes P P Villar P S PS Tarifeño-Saldivia E E Salgado M M Elizondo-Vega R R Araneda Ricardo C RC García-Robles María A MA
Scientific reports 20211104 1
Previous studies indicate that the activity of hypothalamic POMC neurons can be regulated by glucose via intracellular mechanisms, but its regulation by lactate is poorly understood. In addition to its energetic role, lactate acts as a signaling molecule. In this study, we evaluated the function and location of the lactate receptor, hydroxycarboxylic acid receptor 1 (HCAR1). We used a conditional genetic approach to label POMC neurons and evaluated their sensitivity to lactate using patch-clamp ...[more]