Ontology highlight
ABSTRACT:
SUBMITTER: Fujinaga K
PROVIDER: S-EPMC3467075 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Fujinaga Koh K Barboric Matjaz M Li Qintong Q Luo Zeping Z Price David H DH Peterlin B Matija BM
Nucleic acids research 20120720 18
The positive transcription elongation factor b (P-TEFb) regulates RNA polymerase II elongation. In cells, P-TEFb partitions between small active and larger inactive states. In the latter, HEXIM1 binds to 7SK snRNA and recruits as well as inactivates P-TEFb in the 7SK snRNP. Several stimuli can affect this P-TEFb equilibrium. In this study, we demonstrate that protein kinase C (PKC) phosphorylates the serine at position158 (S158) in HEXIM1. This phosphorylated HEXIM1 protein neither binds to 7SK ...[more]