Ontology highlight
ABSTRACT:
SUBMITTER: Furlan A
PROVIDER: S-EPMC6838758 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Furlan Alessandro A Gonzalez-Pisfil Mariano M Leray Aymeric A Champelovier Dorian D Henry Mélanie M Le Nézet Corentin C Bensaude Oliver O Lefranc Marc M Wohland Thorsten T Vandenbunder Bernard B Bidaux Gabriel G Héliot Laurent L
Biophysical journal 20190920 9
How nuclear proteins diffuse and find their targets remains a key question in the transcription field. Dynamic proteins in the nucleus are classically subdiffusive and undergo anomalous diffusion, yet the underlying physical mechanisms are still debated. In this study, we explore the contribution of interactions to the generation of anomalous diffusion by the means of fluorescence spectroscopy and simulation. Using interaction-deficient mutants, our study indicates that HEXIM1 interactions with ...[more]