Dataset Information

Effects of nicotine mouth spray on urges to smoke, a randomised clinical trial.

ABSTRACT:

Objective

A new nicotine mouth spray was shown to be an effective stop-smoking treatment. This study was set up to examine the speed with which it relieves urges to smoke, and how it compares with nicotine lozenge in this respect.

Design

Randomised, cross-over trial that compared nicotine mouth spray 2 mg versus nicotine lozenge 2 or 4 mg.

Setting

Clinical pharmacology research unit.

Participants

200 Volunteer smokers who smoked their first cigarette of the day within 30 min of waking.

Interventions

Subjects abstained from smoking the night before the morning they attended the laboratory. Treatment was administered following 5 h of witnessed abstinence.

Primary and secondary outcome measures

Urge to smoke was rated before and at 1, 3, 5, 10, 15, 25, 30, 45 min and 1, 1.5, and 2 h after treatment administration. The primary outcome concerned change during the first 1, 3 and 5 min after treatment administration.

Results

Nicotine mouth spray achieved greater reductions in craving than either lozenge during the first 1, 3 and 5 min postadministration. After using mouth spray, half of the users experienced 50% reduction in craving within 3.40 min, while the same treatment effect was achieved within 9.92 and 9.20 min for the 2 and 4 mg lozenge, respectively. Adverse events with both mouth spray and lozenge were mostly mild. Hiccups, local irritation, nausea and dyspepsia were more frequent with spray than lozenge.

Conclusions

Nicotine mouth spray provides a faster relief of cravings than nicotine lozenge.

SUBMITTER: Hansson A

PROVIDER: S-EPMC3467658 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Effects of nicotine mouth spray on urges to smoke, a randomised clinical trial.

Hansson Anna A Hajek Peter P Perfekt Roland R Kraiczi Holger H

BMJ open 20120926 5

<h4>Objective</h4>A new nicotine mouth spray was shown to be an effective stop-smoking treatment. This study was set up to examine the speed with which it relieves urges to smoke, and how it compares with nicotine lozenge in this respect.<h4>Design</h4>Randomised, cross-over trial that compared nicotine mouth spray 2 mg versus nicotine lozenge 2 or 4 mg.<h4>Setting</h4>Clinical pharmacology research unit.<h4>Participants</h4>200 Volunteer smokers who smoked their first cigarette of the day withi ...[more]

PMID: 23015605

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Dataset Information

Effects of nicotine mouth spray on urges to smoke, a randomised clinical trial.

Objective

Design

Setting

Participants

Interventions

Primary and secondary outcome measures

Results

Conclusions

Publications

Effects of nicotine mouth spray on urges to smoke, a randomised clinical trial.

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