An evidence-based review of the potential role of icatibant in the treatment of acute attacks in hereditary angioedema type I and II.

ABSTRACT: INTRODUCTION:Icatibant, a first-in-class B2 bradykinin receptor antagonist, appears to have a favorable efficacy and safety profile for the treatment of acute attacks of hereditary angioedema in adults. AIMS:To update the evidence and provide an overview of the available data on icatibant. EVIDENCE REVIEW:Peer reviewed articles published and listed in Medline Search and published updated guidelines for the treatment of acute attacks in hereditary angioedema type I and II in adults were reviewed. The validity and quality of evidence were evaluated. PLACE IN THERAPY:Clinical evidence for the treatment of acute hereditary angioedema attacks with icatibant is strong. Approximately 10% of the patients require a second dose. No serious adverse reactions have been reported. The only significant side effects consistently registered by 90% of patients are transient local pain, swelling, and erythema at the local injection site. CONCLUSION:Subcutaneously administered 30 mg icatibant has been shown to be a safe and efficacious treatment in clinical trials. It is the only specific treatment authorized for self-administration by the subcutaneous route offering increased patient independence.

SUBMITTER: Floccard B 

PROVIDER: S-EPMC3467996 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature